Andrea PAPPALARDO

Associate Professor of [CHIM/06]
Office: Cittadella Universitaria, V.le A. Doria 6, 95125 Catania. Edificio 1 corpo A piano 2 Stanza 1 (A2/1)
Email: andrea.pappalardo@unict.it
Phone: +39 095 738 5010


Andrea Pappalardo Associate Professor of Organic Chemistry, (SSD) 03/C1  -  CHIM/06

CoursesOrganic Chemistry I and Laboratory at the B.D. course of Industrial Chemistry; Novel Synthetic Methodologies at the M.D. course in Organic and Biorganic Chemistry; Organic Chemistry at the B.D. course of Biological Sciences.

Main research topics:

  1. Macrocyclic systems
  2. Supramolecular chemistry
  3. Molecular recognition

ORCID ID: 0000-0003-3321-7970

He was born in Catania in 1974, in 1999 he achieved the degree in Chemistry and Pharmaceutical Technologies at the University of Catania. In 1999 worked for the Department of Physical and Chemical Methodologies for the Engineering of the University of Catania of 5 month-old duration. In 2000 he overcomed the examination of qualification to the exercise of the profession of farmacist.In 2003 he achieved the PhD in Chemical Sciences at the University of Catania. In 2003 he had a Post-Doc position at the Department of Organic Chemistry of the University of Catania of 1 year-old duration working on a project titled: "Design and synthesis of macrocyclic catalysts (calixarenes and resorcarenes) with salen moieties for enantioselective epoxidation". In 2004 he had a Post-Doc position at the Department of Organic and Biological Chemistry of the University of Messina of 4 year-old duration working on a project titled: " Ordered-structured assemblies of calixarenes and ionic species". In 2007 he become a university researcher of Organic Chemistry at the Department of Chemical Sciences of the University of Catania. From 2018 he is Associate Professor of Organic Chemistry. In 1999 his research activity started, it is proven by 56 international publications and 42 congresses communications. Such activity has been developed at the Department of Chemical Sciences and the Department of Physical and Chemical Methodologies for the Engineering of the University of Catania and at the Department of Organic and Biological Chemistry of the University of Messina. The publications are concerned on the synthesis of calixarene macrocycles and their use as catalysts in enantioselective epoxidations, and receptors in the supramolecolar host/guest chemistry.

1.        Manganaro N., Pisagatti I., Notti A., Pappalardo A., Patanè S., Micali N., Villari V., Parisi M. F., Gattuso G. “Ring-chain morphology control in overall-neutral, internally ion-paired supramolecular polymers”. Chemistry - A European Journal 2018, 24, 1097-1103.

 

2.        Trusso Sfrazzetto, G., Millesi, S., Pappalardo, A., Tomaselli, G.A., Ballistreri, F.P., Toscano, R.M., Fragalà, I., Gulino, A. “Nerve Gas Simulant Sensing by a Uranyl–Salen Monolayer Covalently Anchored on Quartz Substrates”. Chemistry - A European Journal 2017, 23, 1576-1583.

 

3.        Puglisi, R., Ballistreri, F.P., Gangemi, C.M.A., Toscano, R.M., Tomaselli, G.A., Pappalardo, A., Sfrazzetto, G.T. “Chiral Zn-salen complexes: a new class of fluorescent receptors for enantiodiscrimination of chiral amines”. New Journal of Chemistry 2017, 41, 911-915.

 

4.        Ballistreri, F.P., Gangemi, C.M.A., Pappalardo, A., Tomaselli, G.A., Toscano, R.M., Sfrazzetto, G.T. “(Salen)Mn(III) catalyzed asymmetric epoxidation reactions by hydrogen peroxide in water: A green protocol”. International Journal of Molecular Sciences 2016, 17, 1112.

 

5.        Fraix, A., Torrisi, V., Marletta, G., Sortino, S., Mineo, P.G., Tomaselli, G.A., Ballistreri, F.P., Trusso Sfrazzetto, G., Pappalardo, A. “Supramolecular polymer networks based on calix[5]arene chained poly(p-phenyleneethynylene) and C60-fulleropyrrolidine”. Supramolecular Chemistry 2016, 28, 485-492. Corresponding author

 

6.        Ballistreri, F.P., Brancatelli, G., Demitri, N., Geremia, S., Guldi, D.M., Melchionna, M., Pappalardo, A., Prato, M., Tomaselli, G.A., Sfrazzetto, G.T. “Recognition of C60 by tetra- and tri-quinoxaline cavitands”. Supramolecular Chemistry 2016, 28, 601-607.

 

7.        Tuccitto, N., Sfrazzetto, G.T., Gangemi, C.M.A., Ballistreri, F.P., Toscano, R.M., Tomaselli, G.A., Pappalardo, A., Marletta, G. “The memory-driven order-disorder transition of a 3D-supramolecular architecture based on calix[5]arene and porphyrin derivatives”. Chemical Communications 2016, 52, 11681-11684. Corresponding author

 

8.        Berardozzi, R., Pescitelli, G., Di Pietro, S., Resta, C., Ballistreri, F.P., Pappalardo, A., Tomaselli, G.A., Di Bari, L. “Synthesis, Structural Characterization, and Chiroptical Studies of Bidentate Salen-Type Lanthanide (III) Complexes”. Chirality 2015, 27, 857-863.

 

9.        Arena, G., Pappalardo, A., Pappalardo, S., Gattuso, G., Notti, A., Parisi, M.F., Pisagatti, I., Sgarlata, C. “Complexation of biologically active amines by a water-soluble calix[5]arene: A nanocalorimetric investigation”. Journal of Thermal Analysis and Calorimetry 2015, 121, 1073-1079.

 

10.      Forte, G., Trusso Sfrazzetto, G., Pappalardo, A. “A DFT study on the recognition of α-amino acid derivatives by chiral uranyl-salen”. Computational and Theoretical Chemistry 2015, 1068, 8-12.

 

11.      Gangemi, C.M.A., Randazzo, R., Fragalà, M.E., Tomaselli, G.A., Ballistreri, F.P., Pappalardo, A., Toscano, R.M., Sfrazzetto, G.T., Purrello, R., D'Urso, A. “Hierarchically controlled protonation/aggregation of a porphyrin-spermine derivative”. New Journal of Chemistry 2015, 39, 6722-6725.

 

12.      Forte, G., D'Urso, A., Ballistreri, F.P., Toscano, R.M., Tomaselli, G.A., Trusso Sfrazzetto, G., Pappalardo, A. “Enantiomeric recognition of α-amino acid derivatives by chiral uranyl-salen receptors”. Tetrahedron Letters 2015, 56, 2922-2926. Corresponding author

 

13.      Trusso Sfrazzetto, G., Millesi, S., Pappalardo, A., Toscano, R.M., Ballistreri, F.P., Tomaselli, G.A., Gulino, A. “Olefin epoxidation by a (salen)Mn(III) catalyst covalently grafted on glass beads”. Catalysis Science and Technology 2015, 5, 673-679.

 

14.      Gangemi, C.M.A., Pappalardo, A., Trusso Sfrazzetto, G. “Applications of supramolecular capsules derived from resorcin[4]arenes, calix[n]arenes and metallo-ligands: from biology to catalysis”. RSC Advances 2015, 5, 51919-51933. Corresponding author

 

15.      Gangemi, C.M.A., Pappalardo, A., Trusso Sfrazzetto, G. “Assembling of supramolecular capsules with resorcin[4]arene and calix[n]arene building blocks”. Current Organic Chemistry 2015, 19, 2281-2308. Corresponding author

 

16.      D'Urso, A., Tudisco, C., Ballistreri, F.P., Condorelli, G.G., Randazzo, R., Tomaselli, G.A., Toscano, R.M., Sfrazzetto, G.T., Pappalardo, A. “Enantioselective extraction mediated by a chiral cavitand-salen covalently assembled on a porous silicon surface”. Chemical Communications 2014, 50, 4993-4996. Corresponding author

 

17.      Bonaccorso, C., Brancatelli, G., Ballistreri, F.P., Geremia, S., Pappalardo, A., Tomaselli, G.A., Toscano, R.M., Sciotto, D. “Novel chiral (salen)Mn(iii) complexes containing a calix[4]arene unit in 1,3-alternate conformation as catalysts for enantioselective epoxidation reactions of (Z)-aryl alkenes”. Dalton Transactions 2014, 43, 2183-2193.

 

18.      Amato, M.E., Ballistreri, F.P., Pappalardo, A., Tomaselli, G.A., Toscano, R.M., Sfrazzetto, G.T. “Selective oxidation reactions of natural compounds with hydrogen peroxide mediated by methyltrioxorhenium”. Molecules 2013, 18, 13754-13763.

 

19.      Pappalardo, A., Amato, M.E., Ballistreri, F.P., La Paglia Fragola, V., Tomaselli, G.A., Toscano, R.M., Trusso Sfrazzetto, G. “Binding of reactive organophosphate by oximes via hydrogen bond”. Journal of Chemical Sciences 2013, 125, 869-873.

 

20.      Satriano, C., Sfrazzetto, G.T., Amato, M.E., Ballistreri, F.P., Copani, A., Giuffrida, M.L., Grasso, G., Pappalardo, A., Rizzarelli, E., Tomaselli, G.A., Toscano, R.M. “A ratiometric naphthalimide sensor for live cell imaging of copper(I)”. Chemical Communications 2013, 49, 5565-5567.

 

21.      Brancatelli, G., Pappalardo, A., Trusso Sfrazzetto, G., Notti, A., Geremia, S. “Mono- and dinuclear uranyl(VI) complexes with chiral Schiff base ligand”. Inorganica Chimica Acta 2013, 396, 25-29. Corresponding author

 

22.      Gattuso, G., Notti, A., Pappalardo, A., Pappalardo, S., Parisi, M.F., Puntoriero, F. “A supramolecular amphiphile from a new water-soluble calix[5]arene and n-dodecylammonium chloride”. Tetrahedron Letters 2013, 54, 188-191.

 

23.      Pappalardo, A., Amato, M.E., Ballistreri, F.P., Notti, A., Tomaselli, G.A., Toscano, R.M., Sfrazzetto, G.T. “Synthesis and topology of [2+2] calix[4]resorcarene-based chiral cavitand-salen macrocycles”. Tetrahedron Letters 2012, 53, 7150-7153. Corresponding author

 

24.      Gargiulli, C., Gattuso, G., Notti, A., Nicoló, F., Pappalardo, A. “31-Benzyloxy-5,11,17,23,29-penta-tert-butylcalix[5]arene-32,33,34, 35-tetraol”. Acta Crystallographica Section E: Structure Reports Online 2012, 68 (12).

 

25.      La Paglia Fragola, V., Lupo, F., Pappalardo, A., Trusso Sfrazzetto, G., Toscano, R.M., Ballistreri, F.P., Tomaselli, G.A., Gulino, A. “A surface-confined O=MnV(salen) oxene catalyst and high turnover values in asymmetric epoxidation of unfunctionalized olefins”. Journal of Materials Chemistry 2012, 22, 20561-20565.

 

26.      Pappalardo, A., Ballistreri, F.P., Destri, G.L., Mineo, P.G., Tomaselli, G.A., Toscano, R.M., Trusso Sfrazzetto, G. “Supramolecular polymer networks based on calix[5]arene tethered poly(p-phenyleneethynylene)”. Macromolecules 2012, 45, 7549-7556. Corresponding author

 

27.      Pappalardo, A., Amato, M.E., Ballistreri, F.P., Tomaselli, G.A., Toscano, R.M., Trusso Sfrazzetto, G. “Pair of diastereomeric uranyl salen cavitands displaying opposite enantiodiscrimination of α-amino acid ammonium salts”. Journal of Organic Chemistry 2012, 77, 7684-7687. Corresponding author

 

28.      Villari, V., Gattuso, G., Notti, A., Pappalardo, A., Micali, N. “Self-assembled calixarene derivative as a supramolecular polymer”. Journal of Physical Chemistry B 2012, 116, 5537-5541.

 

29.      D'Urso, A., Nicotra, P.F., Centonze, G., Fragalà, M.E., Gattuso, G., Notti, A., Pappalardo, A., Pappalardo, S., Parisi, M.F., Purrello, R. “Induction of chirality in porphyrin-(bis)calixarene assemblies: A mixed covalent-non-covalent vs a fully non-covalent approach”. Chemical Communications 2012, 48, 4046-4048.

 

30.      Lombardo, G.M., Thompson, A.L., Ballistreri, F.P., Pappalardo, A., Sfrazzetto, G.T., Tomaselli, G.A., Toscano, R.M., Punzo, F. “An integrated X-ray and molecular dynamics study of uranyl-salen structures and properties”. Dalton Transactions 2012, 41, 1951-1960.

 

31.      Cristaldi, D.A., Fragalà, I., Pappalardo, A., Toscano, R.M., Ballistreri, F.P., Tomaselli, G.A., Gulino, A. “Sensing of linear alkylammonium ions by a 5-pyrenoylamido-calix[5]arene solution and monolayer using luminescence measurements”. Journal of Materials Chemistry 2012, 22, 675-683. Corresponding author

 

32.      Capici, C., Cohen, Y., D'Urso, A., Gattuso, G., Notti, A., Pappalardo, A., Pappalardo, S., Parisi, M.F., Purrello, R., Slovak, S., Villari, V. “Anion-assisted supramolecular polymerization: From achiral AB-type monomers to chiral assemblies”. Angewandte Chemie - International Edition 2011, 50, 11956-11961.

 

33.      Gattuso, G., Grasso, G., Marino, N., Notti, A., Pappalardo, A., Pappalardo, S., Parisi, M.F. “Amino surface-functionalized tris(calix[4]arene) dendrons with rigid C 3-symmetric propeller cores”. European Journal of Organic Chemistry 2011, 5696-5703.

 

34.      Amato, M.E., Ballistreri, F.P., D'Agata, S., Pappalardo, A., Tomaselli, G.A., Toscano, R.M., Sfrazzetto, G.T. “Enantioselective molecular recognition of chiral organic ammonium ions and amino acids using cavitand-salen-based receptors”. European Journal of Organic Chemistry 2011, 5674-5680.

 

35.      Tudisco, C., Sfrazzetto, G.T., Pappalardo, A., Motta, A., Tomaselli, G.A., Fragalà, I.L., Ballistreri, F.P., Condorelli, G.G. “Covalent functionalization of silicon surfaces with a cavitand-modified salen”. European Journal of Inorganic Chemistry 2011, 2124-2131.

 

36.      Ballistreri, F.P., Gentile, S., Pappalardo, A., Tomaselli, G.A., Pradhan, S., Di Bari, L. “Reversible mutarotation in a macrocyclic ytterbium complex”. Chemistry - A European Journal 2011, 17, 322-328.

 

37.      Ballistreri, F.P., Pappalardo, A., Tomaselli, G.A., Sfrazzetto, G.T., Vittorino, E., Sortino, S. “Synthesis and photophysics of a fullerene-triquinoxaline ensemble”. New Journal of Chemistry 2010, 34, 2828-2834.

 

38.      D'Urso, A., Cristaldi, D.A., Fragalà, M.E., Gattuso, G., Pappalardo, A., Villari, V., Micali, N., Pappalardo, S., Parisi, M.F., Purrello, R. “Sequence, stoichiometry, and dimensionality control in porphyrin/ biscalix[4]arene self-assemblies in aqueous solution”. Chemistry - A European Journal 2010, 16, 10439-10446.

 

39.      Ballistreri, F.P., Pappalardo, A., Tomaselli, G.A., Toscano, R.M., Trusso Sfrazzetto, G. “Heteroditopic chiral uranyl-salen receptor for molecular recognition of amino acid ammonium salts”. European Journal of Organic Chemistry 2010, 3806-3810. Corresponding author

 

40.      Lupo, F., Capici, C., Gattuso, G., Notti, A., Parisi, M.F., Pappalardo, A., Pappalardo, S., Gulino, A. “Optical recognition of n -butylammonium and 1,5-pentanediammonium picrates by a calix[5]arene monolayer covalently assembled on silica substrates”. Chemistry of Materials 2010, 22, 2829-2834.

 

41.      Amato, M.E., Ballistreri, F.P., Gentile, S., Pappalardo, A., Tomaselli, G.A., Toscano, R.M. “Recognition of achiral and chiral ammonium salts by neutral ditopic receptors based on chiral salen-UO2 macrocycles”. Journal of Organic Chemistry 2010, 75, 1437-1443.

 

42.      Amato, M.E., Ballistreri, F.P., Pappalardo, A., Tomaselli, G.A., Toscano, R.M. “Synthesis and conformational study of a novel macrocyclic chiral(salen) ligand and its uranyl and Mn complexes”. Molecules 2010, 15, 1442-1452.

 

43.      Gattuso, G., Notti, A., Parisi, M.F., Pisagatti, I., Amato, M.E., Pappalardo, A., Pappalardo, S. “Threading the calix[5]arene annulus”. Chemistry - A European Journal 2010, 16, 2381-2385.

 

44.      Ballistreri, F.P., Fortuna, C.G., Pappalardo, A., Tomaselli, G.A., Toscano, R.M. “Oxidation of organic sulfides by a vanadium(5+) oxo-monoperoxo-picolinate complex: Kinetics and mechanism” . Journal of Molecular Catalysis A: Chemical 2009, 308, 56-60.

 

45.      Gattuso, G., Notti, A., Pappalardo, A., Parisi, M.F., Pisagatti, I., Pappalardo, S., Garozzo, D., Messina, A., Cohen, Y., Slovak, S. “Self-assembly dynamics of modular homoditopic bis-calix[5]arenes and long-chain α,ω-alkanediyldiammonium components”. Journal of Organic Chemistry 2008, 73, 7280-7289.

 

46.      Pappalardo, S., Villari, V., Slovak, S., Cohen, Y., Gattuso, G., Notti, A., Pappalardo, A., Pisagatti, I., Parisi, M.F. “Counterion-dependent proton-driven self-assembly of linear supramolecular oligomers based on amino-calix[5]arene building blocks”. Chemistry - A European Journal 2007, 13, 8164-8173.

 

47.      Amato, M.E., Ballistreri, F.P., Pappalardo, A., Sciotto, D., Tomaselli, G.A., Toscano, R.M. “Synthesis and conformational aspects of 20- and 40-membered macrocyclic mono and dinuclear uranyl complexes incorporating salen and (R)-BINOL units”. Tetrahedron 2007, 63, 9751-9757.

 

48.      Gattuso, G., Pappalardo, A., Parisi, M.F., Pisagatti, I., Crea, F., Liantonio, R., Metrangolo, P., Navarrini, W., Resnati, G., Pilati, T., Pappalardo, S. “Dipyridinocalixcrown/diiodoperfluorocarbon binary host systems for CsI: structural studies and fluorous phase extraction of caesium”. Tetrahedron 2007, 63, 4951-4958.

 

49.      Buscemi, S., Pace, A., Piccionello, A.P., Pappalardo, S., Garozzo, D., Pilati, T., Gattuso, G., Pappalardo, A., Pisagatti, I., Parisi, M.F. “Lower rim arylation of calix[n]arenes with extended perfluorinated domains”. Tetrahedron Letters 2006, 47, 9049-9052.

 

50.      Gattuso, G., Liantonio, R., Metrangolo, P., Meyer, F., Pappalardo, A., Parisi, M.F., Pilati, T., Pisagatti, I., Resnati, G. “Hybrid calixarene/inorganic salt/diiodoperfluorocarbon supramolecular assemblies”. Supramolecular Chemistry 2006, 18, 235-243.

 

51.      Amato, M.E., Ballistreri, F.P., Pappalardo, A., Tomaselli, G.A., Toscano, R.M., Williams, D.J. “Novel chiral (salen)MnIII complexes containing a calix[4]arene unit as catalysts for enantioselective epoxidation reactions of (Z)-aryl alkenes”. European Journal of Organic Chemistry 2005, 3562-3570.

 

52.      Garozzo, D., Gattuso, G., Notti, A., Pappalardo, A., Pappalardo, S., Parisi, M.F., Perez, M., Pisagatti, I. “A calix[5]arene-based heterotetratopic host for molecular recognition of long-chain, ion-paired α,ω-alkanediyldiammonium salts”. Angewandte Chemie - International Edition 2005, 44, 4892-4896.

 

53.      Marrazzo, A., Pappalardo, A., Prezzavento, O., Vittorio, F., Ronsisvalle, G. “1-Phenyl-3-azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors”. Arkivoc 2004, 156-169.

 

54.      Mamo, A., Pappalardo, A. “Synthesis and characterization of acyclic and cyclic aza-bridged ligands incorporating 2,2′-bipyridine subunits and their complexes with copper(II), cobalt(II), and nickel(II)”. Molecules 2003, 8, 521-535.

55.      Mamo, A., Pappalardo, A., Clasadonte, M.T. “Sulfur bridged multidentate ligands based on (bi)pyridyl-(bi)-1,3,4- thiadiazolyl conjugates”. Molecules 2003, 8, 310-317.


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