ORGANIC CHEMISTRY II

Learning Objectives

• MODULO 2

  Acquire experiences on the methodologies and techniques on the organic synthesis through the preparation of some products and their identification.

Detailed Course Content

• MODULO 1

  Aromatic hydrocarbons. Aromatic substitution reactions. Aromatic nucleophilic reactions. Phenols. Pericyclic reactions. Carbanions as nucleophiles. Biomolecules (Lipids,Carbohydrates,Aminoacids,Proteins, Nucleic acids). Pentatomic Heterocycles. Pyridine. The disconnession approach.

• MODULO 2

  Introductive ideas on common identification techniques as: ¹H - e ¹³C-NMR, UV-Vis, GC, GC/MS e HPLC.

  Practical execution of electrophilic aromatic substitution, carbonyl addition-elimination reactions, local anesthetic multistage synthesis and oxygen transfer to alkenes. Use of environmentally friendly solvents (H₂O, ionic liquids, ecc.).

  Isolation, purification and characterization of the products obtained in the experiences through: : p.f., UV-Vis, IR, ¹H- e ¹³C-NMR.

Textbook Information

• MODULO 1

  1. Chimica Organica 5e Edises Brown/Foote/Iverson/Anslyn

  2. Guida alla soluzione dei problemi da introduzione alla chimica organica

  Felix S. Lee- William H. Brown-Thomas Poon Edises

  3. Class notes (Slides)

• MODULO 2

  1. D.L. Pavia, G.M. Lampman, G.S. Kritz, Introduction to Organic Laboratory, Saunder College Pubblishing.

  2. R.M. Silverstein, F.X. Webster, Identificazione Spettroscopica di Composti Organici,

  Ambrosiana.