ORGANIC CHEMISTRY II A - L

Learning Objectives

• MODULO 1

  The course target is, by means of common organic reaction mechanisms analysis, to develope student ability to correlate organic molecules (including some classes of biomolecules such as fat acids, aminoacids, peptides and carbohydrates) properties and reactivities with their structures and to design synthetic strategies to prepare relatively simple target organic molecules after acquiring the fundamental principles of disconnession approach.

• MODULO 2

  Acquire experiences on the methodologies and techniques on the organic synthesis through the preparation of some products and their identification.

Detailed Course Content

• MODULO 1

  Aromatic hydrocarbons. Aromatic substitution reactions. Aromatic nucleophilic reactions. Phenols. Pericyclic reactions. Carbanions as nucleophiles. Biomolecules (Lipids,Carbohydrates,Aminoacids,Proteins, Nucleic acids). Pentatomic Heterocycles. Pyridine. The disconnession approach.

• MODULO 2

  Introductive ideas on common identification techniques as: ¹H - e ¹³C-NMR, UV-Vis, GC, GC/MS e HPLC.

  Practical execution of electrophilic aromatic substitution, carbonyl addition-elimination reactions, local anesthetic multistage synthesis and oxygen transfer to alkenes. Use of environmentally friendly solvents (H₂O, ionic liquids, ecc.).

  Isolation, purification and characterization of the products obtained in the experiences through: : p.f., UV-Vis, IR, ¹H- e ¹³C-NMR.

Textbook Information

• MODULO 1

  1. Chimica Organica 5e Edises Brown/Foote/Iverson/Anslyn

  2. Guida alla soluzione dei problemi da introduzione alla chimica organica

  Felix S. Lee- William H. Brown-Thomas Poon Edises

  3. Class notes (Slides)

• MODULO 2

  1. D.L. Pavia, G.M. Lampman, G.S. Kritz, Introduction to Organic Laboratory, Saunder College Pubblishing.

  2. R.M. Silverstein, F.X. Webster, Identificazione Spettroscopica di Composti Organici,

  Ambrosiana.