CHEMISTRY OF BIOACTIVE NATURAL PRODUCTS
Academic Year 2015/2016 - 1° Year
Teaching Staff: Corrado TRINGALI
Credit Value: 6
Scientific field: CHIM/06 - Organic chemistry
Taught classes: 48 hours
Term / Semester: 2°
Credit Value: 6
Scientific field: CHIM/06 - Organic chemistry
Taught classes: 48 hours
Term / Semester: 2°
Detailed Course Content
Introduction. Drug discovery and drug development. Structure-activity relationship (SAR). Interaction with receptors. Enzyme inhibitors. Xenobiotics metabolism. Nutraceuticals and cancer chemoprevention.
Acetate biosynthetical pathway.
Mevalonate biosynthetical pathway.
Shikimate biosynthetical pathway.
Alkaloids: biosynthesis and properties.
Natural products containing sulphur or alogens.
Textbook Information
1. Paul M. Dewick, Chimica, Biosintesi e Bioattività delle Sostanze Naturali, 2a Ediz.,Piccin
2. Richard B. Silverman, The Organic Chemistry of Drug Discovery and Drug Action, 2nd edition, Elsevier – Academic Press
3. Slides of the lessons