STRATEGY IN ORGANIC SYNTHESIS AND LABORATORY
Academic Year 2016/2017 - 1° YearCredit Value: 6
Scientific field: CHIM/06 - Organic chemistry
Taught classes: 14 hours
Term / Semester: 1°
Learning Objectives
This course is designed to be an intensive survey of the chemical methods and
strategies utilized in modern synthetic organic chemistry, focusing on Chemo-, Regio- and Stereoselectivity aspects. Emphasis will be placed on functional group transformations and carbon-carbon bond forming reactions.
Detailed Course Content
Planning organic syntheses .
Retrosynthetic Analysis. Synthetic strategy based on functional group interconversion, activating groups, reversal of polarity. Protectin groups. The order of events. Chemoselectivity. Regioselectivity. Stereoselectivity.
Organo-main group chemistry in organic synthesis (sulfur, boron, silicon, tin). Cap 46-47
Organometallic reactives. Cap48
Introduction to ring synthesis. Cap29
Total synthesis of interesting and/or useful natural products
Modern strategy in minimizing the environmental impact of human industry and technology
Textbook Information
There are no required texts for this course. However, a number of excellent reference texts can be particularly useful.
F. A. Carey & R. J. Sundberg "Advanced Organic Chemistry, Part B"
Warren, Wyatt- Organic Synthesis: the Disconnection approach 2 ed. Wiley 2011
Clayden, Greeves, Warren, Wothers Organic Chemistry – Oxford Univ Press 2001
Green chemistry