CHIMICA ORGANICA SUPRAMOLECOLARE E LABORATORIO
Academic Year 2023/2024 - Teacher:
GIUSEPPE TRUSSO SFRAZZETTO
Expected Learning Outcomes
The course aims to provide basic information on topics in supramolecular organic chemistry, in particular on the most common practices in the laboratory. The module aims to provide the student with the tools for understanding the formation of supramolecular organic aggregates, with particular reference to organic reactions, and strategies for isolating and characterizing organic supramolecular aggregates. Predicting and deriving the molecular structure of a synthesized supramolecule, or of an unknown supramolecule will be one of the main objectives of the course. Furthermore, one of the main objectives will be to recognize and correctly assemble the laboratory glassware, according to the experience to be carried out.
The specific training objectives of the module will be:
Knowing how to organize and assemble the laboratory glassware for the realization of a supramolecular synthesis;
Knowing how to structurally characterize an organic supramolecule using one or more instrumental techniques;
Knowing how to interpret spectroscopic data in order to trace the identity of an organic supramolecule
To acquire experience on the methodologies and techniques of non-covalent organic synthesis through the preparation of some products and their structural determination.
With reference to the Dublin Descriptors, this course aims to transfer the following transversal skills to the student:
Knowledge and understanding:
Inductive and deductive reasoning skills;
Ability to rationalize and predict the reactivity of organic molecules;
Ability to distinguish the different synthesis techniques;
Ability to distinguish the different laboratory instruments
Ability to apply knowledge:
Ability to design a synthetic path suitable for obtaining a precise organic molecule;
Ability to foresee the necessary instrumentation for the realization of the synthesis;
Ability to identify the optimal reaction conditions for a given reaction.
Autonomy of judgment:
Critical reasoning skills;
Self-assessment of learning through interactions in the classroom with colleagues and with the teacher.
Communication skills:
Ability to describe in oral and written form, with properties of language and terminological rigor, one of the topics covered, using both power point presentations and the blackboard
Course Structure
The course is structured in two sections: a first part of lectures and a second part of laboratory activities
If the teaching is given in a mixed or remote mode, the necessary changes with respect to what was previously stated may be introduced, in order to respect the program envisaged and reported in the syllabus.
Required Prerequisites
Fundamental of Organic Chemistry
Attendance of Lessons
As established by the didactic regulations of the Course of Studies
Detailed Course Content
The course is divided into 4 CFU of theoretical lessons and 2 CFU of laboratory activities.
in particular, theoretical lessons:
Non-covalent interactions
P-greek interactions
Hydrophobic effect
Design of supramolecular architectures
Cooperation, pre-organization and complementarity
Characterization of supramolecular systems
Molecular Capsules
Catenani, Rotaxani and Pseudorotaxani
Synthetic strategies of abiotic supramolecular receptors
Synthetic strategies of Molecular Capsules
The laboratory activity:
Structural characterization of organic supramolecules in solution
Applications of supramolecular structures
Laboratory experiences
Textbook Information
- Appunti delle lezioni
- E.V. Anslyn, D.A.Dougherty "Modern Physical Organic Chemistry" University Science Books
- J.M.Lehn "Supramolecular Chemistry" VCH
Course Planning
| | Subjects | Text References |
|---|
| 1 | non covalent interaction | J.M.Lehn "Supramolecular Chemistry" VCH |
| 2 | pi-pi interactions | J.M.Lehn "Supramolecular Chemistry" VCH |
| 3 | hydrophobic effect | J.M.Lehn "Supramolecular Chemistry" VCH |
| 4 | design of supramolecular structures | notes of lessons |
| 5 | characterization of supramolecular structures | notes of lessons |
| 6 | supramolecular receptors | J.M.Lehn "Supramolecular Chemistry" VCH |
Learning Assessment
Learning Assessment Procedures
The exam modality envisaged consists of an oral exam
Verification of learning can also be carried out electronically, should the conditions require it.
Examples of frequently asked questions and / or exercises
1) Self-assembly
2) molecular capsules
3) synthesis of a supramolecule
