Giuseppe ARENA

Professor of [CHIM/01]
Office: Cittadella Universitaria, V.le A. Doria 6, 95125 Catania. Edificio 1 Corpo B piano 1 Stanza 6 (B1/6)
Phone: +39 095 738 5071
Fax: +39 095 337678

Current Position: Full Professor of Analytical Chemistry

Teaching assignementsAnalytical Chemistry 1 and Laboratory at the B.D. course of Chemistry

Main research interests:

  1. -Thermodynamic and Spectroscopic Studies of bio-functional ligand metal complexes
  2. - Speciation in aqueous solution
  3. - Optimization of calorimetric systems
  4. - Use of new carriers for the removal/determination of species  of interest
  5. - Supramolecular Chemistry

ORCID ID: 0000-0002-3874-7076

Researchgate web address:

Born in Enna, Italy, March 19, 1949. Laurea magna cum laude, Industrial Chemistry (1973), University of Catania.

Academic positions: Research assistant (1974). Post-doctoral fellow, Chemistry Dept., University of St. Andrews, Scotland (1976). Lecturer, University of Catania (1977-1982). Associate Professor (1982-1985). Analytical Chemistry Chair, University of Messina (1985). Analytical Chemistry Chair, University of Catania (1990- up to date). NATO Senior Scientist, Thermochemical Institute, Brigham Young University (BYU) (1984), Lecturer, Chemistry Dept. (BYU) (1984), NATO Senior Scientist (BYU) (1989) and Visiting Professor (BYU) (1998), Provo, Utah, USA.

Publications/Bibliometric parameters: 115 peer-reviewed papers in international Journals, six book chapters. Total No. of Citations: >3500 (>3100 w.o. self-citations); Citations/paper: 31; H-index: 32.

Scientific collaborations with several Italian (Turin, Siena, Palermo, Ferrara, Parma. Messina) as well as foreign (Toronto, BYU, Saarlandes, Fukuoka, Nagoya, Texas Tech.-Lubbock, UC-Berkeley, Ivanovo, Ann Arbour) Universities/Institutions. Link full CV

Chairman and/or member of the Scientific Committees of several National and International Schools/Meetings; over 100 lectures/seminars presented.

Several invited lectures/seminars at Italian (Turin, Bologna, Florence-S. Miniato, Frascati, Roma, Camerino, Ferrara, Palermo) and foreign (Budapest-Hungary, Chisinau-Moldova, UC Berkeley-USA, Brigham Young University-USA, Cape Town-RSA Plyos-Russia, Ivanovo-Russia, Susdal-Russia, MEDICTA-Athens University- Greece, University of Porto-Portugal, Warsaw Technical University-Poland, Aristotle University, Thessaloniki-Greece, ACS Meeting New Orleans-USA, NRC Zakopane-Poland, ISMC – Gdansk-Poland, BYU, Provo-USA, Park City-USA, Fukuoka-Japan, Kazan State University-Russia, University of Nagoya-Japan,  University of Kanazawa-Japan, Kyoto Pharmaceutical University-Japan, University of Saarlandes-Germany, IUPAC- Snowbird-USA, Gandia-Valencia-Spain, ORNL, Oak Ridge, Tennessee-USA, Eurasia-Bangkok- Thailand) Institution/Universities.

Awards: Sunner Memorial Award, The Calorimetry Conference (U.S.A.), Oak Ridge, Tennesse, 1989.

Canneri Medal, Division of Analytical Chemistry - Italian Chemical Society, Sestri Levante (Italy), 2013.

Principal Investigator, Multiple equilibria in natural and biological fluids: from speciation to selective sequestering, PRIN 2015, MIUR, Italy.  Link full CV

Project Manager (University of Catania) of bilateral Agreements with the Department of Chemistry, University of California, Berkeley, USA, the Department of Chemistry, University of Nagoya, Japan. Project Manager (University of Messina) of a bilateral Agreement with the Department of Chemistry, Brigham Young University, Provo, Utah, U.S.A.

Project Manager (University of Catania) of the national research project “Models in Enzymes”.

Project Manager (University of Catania) of a Vigoni project with the Chemistry Department, University of Saarlandes, Saarbrucken (Germany)

Student tutor and Visiting teacher within the framework of a Socrates exchange project with the Warsaw University of Technology, Poland

Referee for International Journals: JACS, Chem. Comm., Inorg. Chem., Angewandte Chemie, J. Supramol. Chem., Thermochim. Acta, Chemistry Eur. J., Eur. J. Inorg. Chem., Eur. J. Org. Chem., J. Inorg. Biochem., Colloid Surf. A, European J. of Med. Chem., J. Membrane Sci., J. Pharm. Biomed. Anal., J. Therm. Anal. Calorim., New J. Chem., Sep. Sci. Technol., J. Polymer Res., Polym. Adv. Technol., React. Funct. Polym., RSC Advances, J. Solution. Chem., J. Incl Phen. Mol. Recognition, Sep. Sci. Technol., Synth. Commun., Tetrahedron Lett., Languimir, ChemPhysChem.


Publications over the last 5 years (ORCID ID: 0000-0002-3874-7076)


Irina Naletova, Cristina Satriano, Alessandra Curci, Nicola Margiotta, Giovanni Natile, Giuseppe Arena, Diego La Mendola, Vincenzo Giuseppe Nicoletti and Enrico Rizzarelli

Cytotoxic phenanthroline derivatives alter metallostasis and redox homeostasis in neuroblastoma cells

Oncotarget, 2018, Vol. 9, (No. 91), pp: 36289-36316,


Effect of reactant solvation on the stability of complexes of silver(I) with 18-crown-6 in ethanol-dimethyl sulfoxide mixtures

Irina A.Kuz'mina,Mariia A.Volkova, Kseniia I.Kuz'mina, Tatiana R.Usacheva, Valentin A.Sharnin, Giuseppe Arena

Journal of Molecular Liquids, accepted

Carmelo Sgarlata, Giuseppe Arena, Raffaele P. Bonomo, Alessandro Giuffrida, Giovanni Tabbì

Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications

J. Inorg. Biochem. 180 (2018) 89–100.



Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E.          

Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity

Eur J Med Chem. 2017 Jul 28;135:447-457. doi: 10.1016/j.ejmech.2017.04.060


Sgarlata,C.; Giuffrida, A.; Trivedi, E.R.; Pecoraro, V.L., Arena, G. "Anion Encapsulation Drives the Formation of Dimeric GdIII [15-metallacrown-5]3+ Complexes in Aqueous Solution"

Inorg. Chem. 2017, 56, 4771-4774


G. Arena, C. Sgarlata

Modern Calorimetry: An Invaluable Tool in Supramolecular Chemistry, In Comprehensive Supramolecular Chemistry II, Vol. 2, J. L. Atwood, G. W. Gokel, L. J. Barbour Eds., Elsevier, 2016, DOI: 10.1016/B978-0-12-409547-2.13716-3


Carmela Bonaccorso, Rossella Migliore, Mariia Volkova, Giuseppe Arena, Carmelo Sgarlata

Self-assembling of supramolecular adducts by sulfonato-calix[4]arene and pyridinium gemini guests in neutral aqueous solution

Thermochimica Acta 656 (2017) 47–52


Carmelo Sgarlata; Jeffrey S. Mugridge; Michael D. Pluth; Valeria Zito; Giuseppe Arena; Kenneth Raymond

Different and often opposing forces drive the encapsulation and multiple exterior binding of charged guests to a M4L6 supramolecular vessel in water

Chemistry, A European Journal, 2017, DOI:10.1002/chem.201703202



C. Sgarlata, G. Arena, C. G. Fortuna, D. Sciotto, C. Bonaccorso

Cationic gemini guests promote the efficient self-assembly of capsular entities in water at neutral pH

Supramolecular Chemistry, 2016, 28, 544–550;


G. Arena, P. Gans, C. Sgarlata

HypCal, a general-purpose computer program for the determination of standard reaction enthalpy and binding constant values by means of calorimetry

Analytical Bioanalytical Chemistry, 2016, 408, 6413–6422                                   


V. Lanza, A. Travaglia, G. Malgieri, R. Fattorusso, G. Grasso, G. Di Natale, V. Zito, G. Arena, D. Milardi, E. Rizzarelli

Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions

Chemistry, A European Journal, 2016, 22, 17767–17775; DOI: 10.1002/chem.201603650                                                                                           



Giuseppe Arena, Andrea Pappalardo, Sebastiano Pappalardo, Giuseppe Gattuso, Anna Notti, Melchiorre F. Parisi, Ilenia Pisagatti, Carmelo Sgarlata

Complexation of biologically active amines by a water-solublec calix[5]arene. A nanocalorimetric investigation

J Therm Anal Calorim,  2015, Volume 121, 3, 1073-1079; DOI 10.1007/s10973-015-4522-3



Giuseppa I. Grasso, Giuseppe Arena, Francesco Bellia, Enrico Rizzarelli and Graziella Vecchio

Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound

J. Inorg. Biochem., 2014, 56-63;  DOI:  10.1016/j.jinorgbio.2013.10.020


Carmela Bonaccorso, Giovanna Brancatelli, Giuseppe Forte, Giuseppe Arena, Silvano Geremia, Domenico Sciotto and Carmelo Sgarlata

Factors driving the self-assembly of water-soluble calix[4]arene and gemini guests: a combined solution, computational and solid-state study

RSC Adv., 2014, 4, 53575; DOI: 10.1039/C4RA09353D

Academic Year  

Thermodynamic and Spectroscopic Studies of bio-functional ligand metal complexes and Speciation in aqueous solution

The analysis of the distribution of species shows the implications of a correct speciation on data interpretation and experiment planning More? ( + + +

Optimization of calorimetric systems

It is shown that the first point anomaly (circle) of an ITC titration is for the vast majority due to a backlash effect in the drive screw mechanism of the syringe. More? Link to

A new software has been developed that allows for the simultaneous determination, from data obtained by isothermal titration calorimetry, of both standard enthalpy of reaction and binding constant values; the program can deal with multiple titrations. More? Link to

Use of new carriers for the removal or detection of undesired species 

A PIM transport system with a substituted calix[4]arene carrier 1 has been established that provides selective Hg(II) transfer from an aqueous source phase containing Cd(II), Hg(II) and Pb(II) into an aqueous receiving phase. More? + 

Chimica Supramolecolare

Data obtained independently by NMR, UV-vis, and isothermal titration calorimetry measure different components of the internal and external guest binding to the host and provide a complete picture of the solution thermodynamics only when analyzed together. More? Link +


NMR, MS and ITC data demonstrate that a simple calixarene-based host forms a homodimeric capsule-like compartments in neutral aqueous solution. More? Link to + + Also gadolinium-based metallacrowns form supramolecular capsule-like compartments with both aromatic and aliphatic dicarboxylates in aqueous solution at neutral pH. More? Link to

Positions covered

President of the Italian Association of Calorimetry and Thermal Analysis (up to date)

President of the Division of Analytical Chemistry, Italian Chemical Society

Board of Directors of the Italian Association of Calorimetry and Thermal Analysis

Chairman of the Interdivisional Group of Calorimetry and Thermal Analysis, Italian Chemical Society

Board of Directors of the Interdivisional Group of Calorimetry and Thermal Analysis, Italian Chemical Society

Vice-President of the Division of Analytical Chemistry, Italian Chemical Society

Coordinator of the PhD in Chemistry, Department of Chemical Sciences, University of Catania

Chairman of the Steering Committee of the Italian Group of Supramolecular Chemistry (up to date)

Technical and Scientific Board of the Thalassographic Institute, CNR, Messina, Italy

Board of Directors, The Calorimetry Conference, USA


Scientific/Editorial Boards: Editorial Boards (Journal of Inclusion Phenomena and Molecular Recognition, Journal Thermal Analysis and Calorimetry, Termochimica Acta, Supramolecular Chemistry) and Regional Editor of the Journal Thermal Analysis and Calorimetry



Member of the:

International Committee for the selection of Full Professors, Aristotle University of Thessaloniki, Greece

Committee for the selection of Associate (University of Rome ‘La Sapienza’, University of Eastern Piedmont, University of Pisa, University of Turin, University of Magna Graecia- Catanzaro, University of Naples, University of Catania) and Assistant ((University of Pisa, University of Rome “La Sapienza”, University of Venice) and Full (University of Turin, University of Foggia) Professors.

Committee for the selection of CNR Research personnel

National Committee for the selection of Full Professors of Analytical Chemistry

Evaluation of Research projects: MIUR, PRIN, Italy, several PhD Theses- University of  Cape Town and  University of  Joannesburg, South Africa.

Collaboration with National Companies: Meridionale Impianti, Italy