METALLOMICA CON ELEMENTI DI PROTEOMICA
Academic Year 2015/2016 - 2° YearCredit Value: 6
Scientific field: CHIM/03 - General and inorganic chemistry
Taught classes: 48 hours
Term / Semester: 1°
Detailed Course Content
Metallomics and The Chemistry of Evolution. Cellular uptake of biometals. Intracellular trafficking of copper and zinc. The network of Metallostasis. The interconnected network of metallome and proteome. Signaling roles of zinc and copper. Proteostasis and evolvability. Protein degradation and metal ion. Proteases. Ubiquitin-Proteasome System, Autofagy. Neurodegeneration and metal ions. Angiogenesis and copper. Metal ions and cancer processes
Textbook Information
The Chemistry of Evolution. The Development of our Ecosystem, R.J.P. Williams, J.J.R. Frausto da Silva. Elsevier, 2006
Biological Inorganic Chemistry, Structure and Reactivity. I. Bertini, H. B. Gray, E. I. Stiefel, J. Selverstone Valentine. University Science Books, 2007
Binding, Transport and Storage of Metal Ions in Biological Cells. Eds. W. Maret, A.G. Wedd. Royal Society of Chemistry. 2014.