Academic Year 2017/2018 - 2° Year
Teaching Staff: Enrico RIZZARELLI
Credit Value: 6
Scientific field: CHIM/03 - General and inorganic chemistry
Taught classes: 42 hours
Term / Semester:

Learning Objectives

Understanding of the role of the metallome in biological processes and its connection with proteome and genome.

Detailed Course Content

Metallomics and The Chemistry of Evolution. Cellular uptake of biometals. Intracellular trafficking of copper and zinc. The network of Metallostasis. The interconnected network of metallome and proteome. Signaling roles of zinc and copper. Proteostasis and evolvability. Protein degradation and metal ion. Proteases. Ubiquitin-Proteasome System, Autofagy. Neurodegeneration and metal ions. Angiogenesis and copper. Metal ions and cancer processes

Textbook Information

The Chemistry of Evolution. The Development of our Ecosystem, R.J.P. Williams, J.J.R. Frausto da Silva. Elsevier, 2006

Biological Inorganic Chemistry, Structure and Reactivity. I. Bertini, H. B. Gray, E. I. Stiefel, J. Selverstone Valentine. University Science Books, 2007

Binding, Transport and Storage of Metal Ions in Biological Cells. Eds. W. Maret, A.G. Wedd. Royal Society of Chemistry. 2014.